We wrote up the core arguments and calculations of this blog post as an article for Lancet Psychiatry. Major depression: a highly heterogeneous disorder Major Depressive Disorder (MDD) is a complex and heterogeneous disorder. The DSM-5 that is commonly used to diagnose patients with MDD requires the presence of at least one of the two … Continue reading 10,377 ways for major depression, but 341,737 ways for melancholia