Category Archives: Depression

New network study: What are good depression symptoms?

Our new paper “What are ‘good’ depression symptoms? Comparing the centrality of DSM and non-DSM symptoms of depression in a network analysis” was published in the Journal of Affective Disorders (PDF). In the paper we develop a novel theoretical and empirical framework to answer the question what a “good” symptom is. Traditionally, all depression symptoms… Read more »

The genetics of major depression remain elusive

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Nature didn’t want our commentary ;) … so we publish it here instead. A commentary by Eiko Fried, Sophie van der Sluis, and Angelique Cramer (PDF) A recent study published in Nature by the CONVERGE consortium1 identified two Single Nucleotide Polymorphisms (SNPs) for Major Depressive Disorder (MDD) that replicated across two samples of Han-Chinese women with… Read more »

Blog about our STAR*D depression heterogeneity paper

John McManamy has written a great piece on depression heterogeneity at healthcentral.com that nicely sums up our study “Depression is not a consistent syndrome: an investigation of unique symptom patterns in the STAR*D study” published in the Journal of Affective Disorders (PDF). His main message: The quick takeaway is that not all depressions are the… Read more »

New review paper on depression symptoms

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BMC Medicine published our new paper “Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential” (PDF). It was published in the section Current Controversies in Psychiatry that “seeks to address the key challenges in mental health from diagnosis to co-morbidities” and “focuses on precision medicine where advances in genetics, epigenetics, biomarkers, treatment… Read more »

New paper on problematic assumptions in depression research

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My first solo album I mean paper was released a few days ago ;). My special thanks to Randolph Nesse, Laura Bringmann, Denny Borsboom, and Francis Tuerlinckx for the great support. The publication titled “Problematic assumptions have slowed down depression research: why symptoms, not syndromes are the way forward” is available as open access paper… Read more »

Bereavement paper published !

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Our new paper “From Loss to Loneliness: The Relationship Between Bereavement and Depressive Symptoms” was just published in the Journal of Abnormal Psychology (PDF). In the paper we examined a prospective cohort of 515 individuals, half of which would experience spousal loss throughout the course of the study (the other half was queried as control… Read more »

Media reaction to our new bereavement paper

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The KU Leuven press office did an amazing job with the press release of our new paper “From Loss to Loneliness: The Relationship Between Bereavement and Depressive Symptoms” (PDF) that was published in the Journal of Abnormal Psychology today. » Fried, E. I., Bockting, C., Arjadi, R., Borsboom, D., Tuerlinckx, F., Cramer, A., Epskamp, S.,… Read more »

New paper on life stress and depression symptoms

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Acta Psychiatrica Scandinavica just published our paper “The differential influence of life stress on individual symptoms of depression”! » Fried, E. I., Nesse, R. M., Guille, C., & Sen, S. (2015). The differential influence of life stress on individual symptoms of depression. Acta Psychiatrica Scandinavica. 1-7, EPub ahead of print. (PDF).

New paper on symptom heterogeneity

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The Journal of Affective Disorders just published our second STAR*D paper! » Fried, E. I., & Nesse, R. M. (2015). Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR*D study. Journal of Affective Disorders, 172, 96–102. (PDF)

Paper on depression symptoms and impairment

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The paper I wrote together with Randolph Nesse about individual symptoms of depression and their differential impact on impairment of psychosocial functioning was just published in PLoS ONE. » Fried, E. I. & Nesse, R. M. (2014). The Impact of Individual Depressive Symptoms on Impairment of Psychosocial Functioning. PLoS ONE, 9(2), e90311. (PDF)

Paper on depression symptoms and risk factors

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Check out our new paper “Depression is more than the sum-score of its parts: individual DSM symptoms have different risk factors” in Psychological Medicine! » Fried, E. I., Nesse, R. M., Zivin, K., Guille. C., & Sen, S. (2013). Depression is more than the sum-score of its parts: individual DSM symptoms have different risk factors…. Read more »