I wrote this commentary together with Adam Chekroud. You can find a PDF version of this commentary here. Introduction The largest and longest investigation of treatment-resistant depression (TRD) to date,… Read more »
Imagine you are a group of scientists and want to find out whether a novel drug X works on a specific problem Y. You run the following study: You enroll… Read more »
(Series: critical commentaries on depression trials. Prior posts: 1, 2, 3, 4) Antidepressants only marginally outperform placebos (Khan & Brown, 2015) – which has led to a number of novel… Read more »
A few months back, a study was published in JAMA Psychiatry claiming that whole-body hyperthermia is an effective treatment for depression (UPDATE: the paper was published in full now on… Read more »
Dr. Fava and colleagues have published an antidepressant trial on adjunctive Brexpiprazole, a novel atypical antipsychotic drug that was developed to treat schizophrenia, in the Journal of Clinical Psychiatry. The… Read more »
Unpublished commentary. PDF, DOI 10.13140/RG.2.1.5149.7362. By: Eiko I. Fried, University of Leuven, Belgium Lauren M. Bylsma, University of Pittsburgh, USA Randolph M. Nesse, Arizona State University, USA After submitting the… Read more »
I recently stumbled across the paper “A metastructural model of mental disorders and pathological personality traits”, authored by Aidan Wright and Leonard Simms in 2015. I enjoyed reading it: it’s… Read more »
Halaris and colleagues published a paper in the Journal of Psychiatric Research in which they studied the impact of the SSRI antidepressant escitalopram (ESC) in a group of 30 depressed… Read more »
Imagine you are the editor of, or reviewer for, a very prestigious scientific journal, and you receive a paper about the efficacy of a novel drug for, say, cancer or… Read more »
Nature didn’t want our commentary ;) … so we publish it here instead. A commentary by Eiko Fried, Sophie van der Sluis, and Angelique Cramer (PDF) A recent study published in… Read more »