Imagine you are the editor of, or reviewer for, a very prestigious scientific journal, and you receive a paper about the efficacy of a novel drug for, say, cancer or HIV. You know that current drugs only work for about 1 out of 3 patients, so there are certainly large incentives to develop new drugs…. Read more »
The folks at The Psychologist were kind enough to publish a short overview piece that summarizes the current problems we are facing in depression research, the problematic assumptions the research community holds about depression that have contributed to this dramatic lack of progress that has gone on for over half a century now, and solutions… Read more »
Our new paper “What are ‘good’ depression symptoms? Comparing the centrality of DSM and non-DSM symptoms of depression in a network analysis” was published in the Journal of Affective Disorders (PDF). In the paper we develop a novel theoretical and empirical framework to answer the question what a “good” symptom is. Traditionally, all depression symptoms… Read more »
I spent the last 2 weeks in Tempe, Arizona, working with the brilliant Randolph Nesse and his lab at the Center of Evolution and Medicine at Arizona State University. During my stay, I was invited to give a lecture on Symptomics, a new research framework we recently developed to tackle challenges psychiatry has been struggling… Read more »
Nature didn’t want our commentary ;) … so we publish it here instead. A commentary by Eiko Fried, Sophie van der Sluis, and Angelique Cramer (PDF) A recent study published in Nature by the CONVERGE consortium1 identified two Single Nucleotide Polymorphisms (SNPs) for Major Depressive Disorder (MDD) that replicated across two samples of Han-Chinese women with… Read more »
John McManamy has written a great piece on depression heterogeneity at healthcentral.com that nicely sums up our study “Depression is not a consistent syndrome: an investigation of unique symptom patterns in the STAR*D study” published in the Journal of Affective Disorders (PDF). His main message: The quick takeaway is that not all depressions are the… Read more »
BMC Medicine published our new paper “Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential” (PDF). It was published in the section Current Controversies in Psychiatry that “seeks to address the key challenges in mental health from diagnosis to co-morbidities” and “focuses on precision medicine where advances in genetics, epigenetics, biomarkers, treatment… Read more »
My first solo album I mean paper was released a few days ago ;). My special thanks to Randolph Nesse, Laura Bringmann, Denny Borsboom, and Francis Tuerlinckx for the great support. The publication titled “Problematic assumptions have slowed down depression research: why symptoms, not syndromes are the way forward” is available as open access paper… Read more »
The presentation about psychopathological symptom networks I gave at ICPS 2015 in Amsterdam, “From Loss to Loneliness: The Relationship Between Bereavement and Depressive Symptoms” (PDF of the study), is online on the website of the open science framework. Don’t hesitate to contact me if you have any questions.
Our new paper “From Loss to Loneliness: The Relationship Between Bereavement and Depressive Symptoms” was just published in the Journal of Abnormal Psychology (PDF). In the paper we examined a prospective cohort of 515 individuals, half of which would experience spousal loss throughout the course of the study (the other half was queried as control… Read more »
The KU Leuven press office did an amazing job with the press release of our new paper “From Loss to Loneliness: The Relationship Between Bereavement and Depressive Symptoms” (PDF) that was published in the Journal of Abnormal Psychology today. » Fried, E. I., Bockting, C., Arjadi, R., Borsboom, D., Tuerlinckx, F., Cramer, A., Epskamp, S.,… Read more »
Acta Psychiatrica Scandinavica just published our paper “The differential influence of life stress on individual symptoms of depression”! » Fried, E. I., Nesse, R. M., Guille, C., & Sen, S. (2015). The differential influence of life stress on individual symptoms of depression. Acta Psychiatrica Scandinavica. 1-7, EPub ahead of print. (PDF).
The Journal of Affective Disorders just published our second STAR*D paper! » Fried, E. I., & Nesse, R. M. (2015). Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR*D study. Journal of Affective Disorders, 172, 96–102. (PDF)
Our commentary regarding the NIMH’s decision to solely fund research investigating the neurobiological roots of mental disorders was published in today’s issue of Nature. » Fried, E. I., Tuerlinckx, F., & Borsboom, D. (2014). Mental health: more than neurobiology. Nature, 508, 458. (PDF)
Starting in May 2014, I will be working as a postdoctoral research fellow on psychopathological network models with a focus on affective disorders in the ‘Research Group of Quantitative Psychology and Individual Differences’ at University of Leuven with Prof. Francis Tuerlinckx, in close collaboration with Prof. Denny Borsboom at University of Amsterdam.